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A recently announced clinical trial using stem cell-derived ocular cells has shown preliminary results that are very promising. The first patients to receive the new treatment for people with wet age-related macular degeneration (AMD) have regained reading vision.

The study is a major milestone for the London Project to Cure Blindness, a partnership between Professor Pete Coffey from University College London and Professor Lyndon da Cruz, a retinal surgeon at Moorfields Eye Hospital NHS Foundation Trust. The Project has also been supported by the UCL Institute of Ophthalmology and the National Institute for Health Research (NIHR).
The results of this ground-breaking clinical study, published in Nature Biotechnology, described the implantation of a specially engineered patch of retinal pigment epithelium cells derived from stem cells to treat people with sudden severe sight loss from wet AMD.

The study investigated whether the diseased cells at the back of the patients’ affected eye could be replenished using the stem cell patch. A specially engineered surgical tool was used to insert the patch under the retina in the affected eye of each patient in an operation lasting one to two hours.

It is hoped that the treatment will also help treat dry AMD in the future. It’s the first description of a complete engineered tissue that has been successfully used in this way. Developed in part by researchers at UC Santa Barbara, the team implanted the retinal eyepatch onto a subject at Moorfields Eye Hospital in London.

In the months before patient Douglas Waters’ surgery, his vision was poor and he couldn’t see anything out of his right eye at all. After the surgery, his eyesight improved so much that he could read the newspaper and help his wife with gardening.

This study represents real progress in regenerative medicine and opens the door on new treatment options for people with age-related macular degeneration,” said the study co-author Coffey, a professor at the University of Santa Barbara’s Neuroscience Research Institute and co-director of the campus’s Center for Stem Cell Biology & Engineering.

“The results suggest that this new therapeutic approach is safe and provides good visual outcomes. The patients who received the treatment had very severe AMD, and their improved vision will go some way towards enhancing their quality of life,” said Lyndon da Cruz, a consultant retinal surgeon at Moorfields Eye Hospital, “We recognize that this is a small group of patients, but we hope that what we have learned from this study will benefit many more in the future.”

 

 

Original Article: http://www.33rdsquare.com/2018/03/stem-cell-treatment-restores-sight-to.html

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